Dexamethasone and estradiol treatment in pregnant rhesus macaques: effects on gestational length, maternal plasma hormones, and fetal growth
MJ Novy, SW Walsh - American journal of obstetrics and gynecology, 1983 - Elsevier
To determine the effects of suppressing fetal and maternal adrenal activity on parturition, we
treated pregnant rhesus macaques with dexamethasone (0.25 to 4.0 mg, twice a day) from
gestation day 130 until delivery (term= 167 days). Long-term dexamethasone treatment
increased gestation length: 71% of fetuses were born postmaturely (after day 175 of
gestation; χ 2= 52.6; P< 0.001). The dexamethasone decreased basal levels of maternal
estradiol and cortisol, but not progesterone, and abolished the prepartum estrogen and …
treated pregnant rhesus macaques with dexamethasone (0.25 to 4.0 mg, twice a day) from
gestation day 130 until delivery (term= 167 days). Long-term dexamethasone treatment
increased gestation length: 71% of fetuses were born postmaturely (after day 175 of
gestation; χ 2= 52.6; P< 0.001). The dexamethasone decreased basal levels of maternal
estradiol and cortisol, but not progesterone, and abolished the prepartum estrogen and …