[HTML][HTML] Distinct glycoprotein Ib/V/IX and integrin αIIbβ3-dependent calcium signals cooperatively regulate platelet adhesion under flow
WS Nesbitt, S Kulkarni, S Giuliano, I Goncalves… - Journal of Biological …, 2002 - ASBMB
We have investigated the calcium signaling relationship between the two major platelet
adhesion receptors, glycoprotein Ib/V/IX (GPIb/V/IX) and integrin α IIb β 3, involved in
regulating platelet adhesion on von Willebrand factor (vWf) under flow. Our studies
demonstrate that GPIb engagement of immobilized vWf elicits a transient calcium spike that
may function to promote reversible arrest of translocating platelets. Subsequent integrin α IIb
β 3 engagement of vWf promotes sustained calcium oscillations that are essential for the …
adhesion receptors, glycoprotein Ib/V/IX (GPIb/V/IX) and integrin α IIb β 3, involved in
regulating platelet adhesion on von Willebrand factor (vWf) under flow. Our studies
demonstrate that GPIb engagement of immobilized vWf elicits a transient calcium spike that
may function to promote reversible arrest of translocating platelets. Subsequent integrin α IIb
β 3 engagement of vWf promotes sustained calcium oscillations that are essential for the …