FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity
V Brinkmann, KR Lynch - Current opinion in immunology, 2002 - Elsevier
V Brinkmann, KR Lynch
Current opinion in immunology, 2002•ElsevierThe novel immunomodulator FTY720 is remarkably effective in models of transplantation
and autoimmunity. Recent data show that phosphorylated FTY720 is an agonist at four
sphingosine 1-phosphate receptors. Stimulation of sphingosine 1-phosphate receptors
leads to sequestration of lymphocytes in secondary lymphatic tissues and thus away from
inflammatory lesions and graft sites.
and autoimmunity. Recent data show that phosphorylated FTY720 is an agonist at four
sphingosine 1-phosphate receptors. Stimulation of sphingosine 1-phosphate receptors
leads to sequestration of lymphocytes in secondary lymphatic tissues and thus away from
inflammatory lesions and graft sites.
The novel immunomodulator FTY720 is remarkably effective in models of transplantation and autoimmunity. Recent data show that phosphorylated FTY720 is an agonist at four sphingosine 1-phosphate receptors. Stimulation of sphingosine 1-phosphate receptors leads to sequestration of lymphocytes in secondary lymphatic tissues and thus away from inflammatory lesions and graft sites.
Elsevier