[HTML][HTML] rab7 activity affects epidermal growth factor: epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome
BP Ceresa, SJ Bahr - Journal of Biological Chemistry, 2006 - ASBMB
The epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinase
family. Ligand (epidermal growth factor or EGF) binding to the EGFR results in the
coordinated activation and integration of biochemical signaling events to mediate cell
growth, migration, and differentiation. One mechanism the cell utilizes to orchestrate these
events is ligand-mediated endocytosis through the canonical clathrin-mediated endocytic
pathway. Identification of proteins that regulate the intracellular movement of the EGF· EGFR …
family. Ligand (epidermal growth factor or EGF) binding to the EGFR results in the
coordinated activation and integration of biochemical signaling events to mediate cell
growth, migration, and differentiation. One mechanism the cell utilizes to orchestrate these
events is ligand-mediated endocytosis through the canonical clathrin-mediated endocytic
pathway. Identification of proteins that regulate the intracellular movement of the EGF· EGFR …