[HTML][HTML] Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and …
FP Coxon, MH Helfrich, B Larijani, M Muzylak… - Journal of Biological …, 2001 - ASBMB
Nitrogen-containing bisphosphonate drugs inhibit bone resorption by inhibiting FPP
synthase and thereby preventing the synthesis of isoprenoid lipids required for protein
prenylation in bone-resorbing osteoclasts. NE10790 is a phosphonocarboxylate analogue
of the potent bisphosphonate risedronate and is a weak anti-resorptive agent. Although
NE10790 was a poor inhibitor of FPP synthase, it did inhibit prenylation in J774
macrophages and osteoclasts, but only of proteins of molecular mass∼ 22–26 kDa, the …
synthase and thereby preventing the synthesis of isoprenoid lipids required for protein
prenylation in bone-resorbing osteoclasts. NE10790 is a phosphonocarboxylate analogue
of the potent bisphosphonate risedronate and is a weak anti-resorptive agent. Although
NE10790 was a poor inhibitor of FPP synthase, it did inhibit prenylation in J774
macrophages and osteoclasts, but only of proteins of molecular mass∼ 22–26 kDa, the …
