[HTML][HTML] MEIS1 and HOXA7 genes in human acute myeloid leukemia
O Afonja, JE Smith Jr, DM Cheng, AS Goldenberg… - Leukemia research, 2000 - Elsevier
Co-activation of Meisl with Hoxa7 or Hoxa9 homeobox genes by retroviral gene insertion
has recently been reported to be leukemogenic in murine myeloid leukemia. In this study we
determined their expression in human leukemia. Most human myeloid leukemia cell lines co-
expressed MEIS1 with HOXA7 and HOXA9. Among patients with acute leukemia, 50% of
AML patients expressed MEIS1, while the majority of ALL patients were negative. A total of
89.5% of patients expressing MEIS1 co-expressed HOXA7. In unadjusted models, poorer …
has recently been reported to be leukemogenic in murine myeloid leukemia. In this study we
determined their expression in human leukemia. Most human myeloid leukemia cell lines co-
expressed MEIS1 with HOXA7 and HOXA9. Among patients with acute leukemia, 50% of
AML patients expressed MEIS1, while the majority of ALL patients were negative. A total of
89.5% of patients expressing MEIS1 co-expressed HOXA7. In unadjusted models, poorer …