Lipid phosphatases in the immune system
G Krystal - Seminars in immunology, 2000 - Elsevier
Seminars in immunology, 2000•Elsevier
In the last 10 years we have come to appreciate the central role that phosphatidylinositol (PI)-
3, 4, 5-P3plays in regulating a vast array of biological responses to extracellular signals. The
level of this phospholipid is low in resting cells but increases rapidly in response to growth
factor/cytokine-stimulated plasma membrane recruitment and activation of PI-3-kinase.
Within the last 3 years three enzymes, SHIP, SHIP2 and PTEN, that play key roles in
regulating the level of PI-3, 4, 5-P3have been cloned. In this review I have attempted to …
3, 4, 5-P3plays in regulating a vast array of biological responses to extracellular signals. The
level of this phospholipid is low in resting cells but increases rapidly in response to growth
factor/cytokine-stimulated plasma membrane recruitment and activation of PI-3-kinase.
Within the last 3 years three enzymes, SHIP, SHIP2 and PTEN, that play key roles in
regulating the level of PI-3, 4, 5-P3have been cloned. In this review I have attempted to …
In the last 10 years we have come to appreciate the central role that phosphatidylinositol (PI)-3,4,5-P3plays in regulating a vast array of biological responses to extracellular signals. The level of this phospholipid is low in resting cells but increases rapidly in response to growth factor/cytokine-stimulated plasma membrane recruitment and activation of PI-3-kinase. Within the last 3 years three enzymes, SHIP, SHIP2 and PTEN, that play key roles in regulating the level of PI-3,4,5-P3have been cloned. In this review I have attempted to summarize our current knowledge regarding these three intriguing phosphatases.
Elsevier