[HTML][HTML] Erm/thyroid transcription factor 1 interactions modulate surfactant protein C transcription
S Lin, AKT Perl, JM Shannon - Journal of Biological Chemistry, 2006 - ASBMB
Expression of surfactant protein C (SP-C), which is restricted to alveolar type II epithelial
cells of the adult lung, is critically dependent on thyroid transcription factor 1 (TTF-1). In the
present study we have demonstrated that Erm, a member of the Ets family of transcription
factors, is expressed in the distal lung epithelium during development and is also restricted
to alveolar type II cells in the adult. Erm was up-regulated by fibroblast growth factors (FGFs)
in culture, and blocking FGF signaling inhibited Erm expression both in vivo and in vitro. The …
cells of the adult lung, is critically dependent on thyroid transcription factor 1 (TTF-1). In the
present study we have demonstrated that Erm, a member of the Ets family of transcription
factors, is expressed in the distal lung epithelium during development and is also restricted
to alveolar type II cells in the adult. Erm was up-regulated by fibroblast growth factors (FGFs)
in culture, and blocking FGF signaling inhibited Erm expression both in vivo and in vitro. The …