The ASPP family: deciding between life and death after DNA damage
EA Slee, X Lu - Toxicology letters, 2003 - Elsevier
It is well established that p53 is a primary target for mutation in human cancer. p53 carries
out the important task of ensuring that damaged DNA is not passed on during cell division, a
duty that it performs by either inhibiting the cell cycle or inducing apoptosis. However, it is
unclear how this decision is made. The recent identification of the ASPP family of proteins,
which act to direct the cell away from cell cycle arrest and towards death following p53
upregulation, may explain how this dilemma is resolved. Furthermore, the observation that …
out the important task of ensuring that damaged DNA is not passed on during cell division, a
duty that it performs by either inhibiting the cell cycle or inducing apoptosis. However, it is
unclear how this decision is made. The recent identification of the ASPP family of proteins,
which act to direct the cell away from cell cycle arrest and towards death following p53
upregulation, may explain how this dilemma is resolved. Furthermore, the observation that …