Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4

CC Chang, R Ciubotariu, JS Manavalan, J Yuan… - Nature …, 2002 - nature.com
CC Chang, R Ciubotariu, JS Manavalan, J Yuan, AI Colovai, F Piazza, S Lederman
Nature immunology, 2002nature.com
Abstract Immunoglobulin-like transcript 3 (ILT3) and ILT4 belong to a family of inhibitory
receptors expressed by human monocytes and dendritic cells. We show here that CD8+
CD28− alloantigen-specific T suppressor (TS) cells induce the up-regulation of ILT3 and
ILT4 on monocytes and dendritic cells, rendering these antigen-presenting cells (APCs)
tolerogenic. Tolerogenic APCs show reduced expression of costimulatory molecules and
induce antigen-specific unresponsiveness in CD4+ T helper cells. Studies of human heart …
Abstract
Immunoglobulin-like transcript 3 (ILT3) and ILT4 belong to a family of inhibitory receptors expressed by human monocytes and dendritic cells. We show here that CD8+CD28 alloantigen-specific T suppressor (TS) cells induce the up-regulation of ILT3 and ILT4 on monocytes and dendritic cells, rendering these antigen-presenting cells (APCs) tolerogenic. Tolerogenic APCs show reduced expression of costimulatory molecules and induce antigen-specific unresponsiveness in CD4+ T helper cells. Studies of human heart transplant recipients showed that rejection-free patients have circulating TS cells, which induce the up-regulation of ILT3 and ILT4 in donor APCs. These findings demonstrate an important mechanism of immune regulation.
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