[HTML][HTML] Nitrated fatty acids: endogenous anti-inflammatory signaling mediators
Nitroalkene derivatives of linoleic acid (LNO 2) and oleic acid (OA-NO 2) are present;
however, their biological functions remain to be fully defined. Herein, we report that LNO 2
and OA-NO 2 inhibit lipopolysaccharide-induced secretion of proinflammatory cytokines in
macrophages independent of nitric oxide formation, peroxisome proliferator-activated
receptor-γ activation, or induction of heme oxygenase-1 expression. The electrophilic nature
of fatty acid nitroalkene derivatives resulted in alkylation of recombinant NF-κB p65 protein …
however, their biological functions remain to be fully defined. Herein, we report that LNO 2
and OA-NO 2 inhibit lipopolysaccharide-induced secretion of proinflammatory cytokines in
macrophages independent of nitric oxide formation, peroxisome proliferator-activated
receptor-γ activation, or induction of heme oxygenase-1 expression. The electrophilic nature
of fatty acid nitroalkene derivatives resulted in alkylation of recombinant NF-κB p65 protein …