[HTML][HTML] Direct activation of the epithelial Na+ channel by phosphatidylinositol 3, 4, 5-trisphosphate and phosphatidylinositol 3, 4-bisphosphate produced by …

Q Tong, N Gamper, JL Medina, MS Shapiro… - Journal of Biological …, 2004 - ASBMB
The phospholipid phosphatidylinositol 4, 5-bisphosphate (PtdIns (4, 5) P 2) is accepted to be
a direct modulator of ion channel activity. The products of phosphoinositide 3-OH kinase
(PI3K), PtdIns (3, 4) P 2 and phosphatidylinositol 3, 4, 5-trisphosphate (PtdIns (3, 4, 5) P 3),
in contrast, are not. We report here activation of the epithelial Na+ channel (ENaC)
reconstituted in Chinese hamster ovary cells by PI3K. Insulin-like growth factor-I also
activated reconstituted ENaC and increased Na+ reabsorption across renal A6 epithelial cell …