Mouse models of age-related macular degeneration

PE Rakoczy, JT Meaghan, S Nusinowitz… - Experimental eye …, 2006 - Elsevier
Recent advances in genetic technologies have greatly accelerated our ability to find disease-
related genes and to generate animal models. The availability of ocular tissues with known
genetic diseases are greatly contributing to our understanding of retinal disease processes
including age-related macular degeneration (AMD), and panretinal and cone
degenerations. While the macula is a highly specialised area of the retina not present in
many mammals, the use of animal models such as mouse strains will give basic physiology …