Asp f I CD4+ TH2-like T-cell lines in allergic bronchopulmonary aspergillosis
AP Knutsen, KR Mueller, AD Levine, B Chouhan… - Journal of Allergy and …, 1994 - Elsevier
Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease caused
by bronchial colonization with Aspergillus fumigatus (Af) characterized by elevated serum
total and Af-specific IgE levels and eosinophilia. In order to examine T-cell reactivity to Af
antigens, six T-cell lines were established from the peripheral blood of patients with ABPA to
Asp f I, an 18 kd protein purified from Af extracts. The Asp f I–specific T-cell lines, analyzed
by flow cytometry, were 100% CD3+ CD4+. Lymphoproliferative responses of the T-cell lines …
by bronchial colonization with Aspergillus fumigatus (Af) characterized by elevated serum
total and Af-specific IgE levels and eosinophilia. In order to examine T-cell reactivity to Af
antigens, six T-cell lines were established from the peripheral blood of patients with ABPA to
Asp f I, an 18 kd protein purified from Af extracts. The Asp f I–specific T-cell lines, analyzed
by flow cytometry, were 100% CD3+ CD4+. Lymphoproliferative responses of the T-cell lines …