Matrix metalloproteinases: they're not just for matrix anymore!
LJ McCawley, LM Matrisian - Current opinion in cell biology, 2001 - Elsevier
LJ McCawley, LM Matrisian
Current opinion in cell biology, 2001•ElsevierThe matrix metalloproteinases (MMPs) have been viewed as bulldozers, destroying the
extracellular matrix to permit normal remodeling and contribute to pathological tissue
destruction and tumor cell invasion. More recently, the identification of specific matrix and
non-matrix substrates for MMPs and the elucidation of the biological consequence of
cleavage indicates that perhaps MMPs should be viewed more as pruning shears, playing
sophisticated roles in modulating normal cellular behavior, cell–cell communication and …
extracellular matrix to permit normal remodeling and contribute to pathological tissue
destruction and tumor cell invasion. More recently, the identification of specific matrix and
non-matrix substrates for MMPs and the elucidation of the biological consequence of
cleavage indicates that perhaps MMPs should be viewed more as pruning shears, playing
sophisticated roles in modulating normal cellular behavior, cell–cell communication and …
The matrix metalloproteinases (MMPs) have been viewed as bulldozers, destroying the extracellular matrix to permit normal remodeling and contribute to pathological tissue destruction and tumor cell invasion. More recently, the identification of specific matrix and non-matrix substrates for MMPs and the elucidation of the biological consequence of cleavage indicates that perhaps MMPs should be viewed more as pruning shears, playing sophisticated roles in modulating normal cellular behavior, cell–cell communication and tumor progression.
Elsevier