[PDF][PDF] Histologic findings in recurrent HBV
SN Thung - Liver transplantation, 2006 - Wiley Online Library
SN Thung
Liver transplantation, 2006•Wiley Online LibraryAbstract Key Concepts: 1 The histopathologic presentation of hepatitis B (HB) infection in
liver allografts is generally similar to that seen in the nonallografts. 2 An atypical pattern of
recurrent HB, ie, fibrosing cholestatic hepatitis (FCH) occurs in a small number of patients.
These patients present with a severe cholestatic syndrome, which may clinically resemble
acute or chronic rejection. 3 There are several other possible causes of acute and chronic
hepatitis in liver allografts that may need to be considered. 4 Hepatitis B virus (HBV) …
liver allografts is generally similar to that seen in the nonallografts. 2 An atypical pattern of
recurrent HB, ie, fibrosing cholestatic hepatitis (FCH) occurs in a small number of patients.
These patients present with a severe cholestatic syndrome, which may clinically resemble
acute or chronic rejection. 3 There are several other possible causes of acute and chronic
hepatitis in liver allografts that may need to be considered. 4 Hepatitis B virus (HBV) …
Abstract
Key Concepts:
- 1The histopathologic presentation of hepatitis B (HB) infection in liver allografts is generally similar to that seen in the nonallografts.
- 2An atypical pattern of recurrent HB, i.e., fibrosing cholestatic hepatitis (FCH) occurs in a small number of patients. These patients present with a severe cholestatic syndrome, which may clinically resemble acute or chronic rejection.
- 3There are several other possible causes of acute and chronic hepatitis in liver allografts that may need to be considered.
- 4Hepatitis B virus (HBV) infection in the liver allograft can easily be confirmed by performing immunohistochemical stains for hepatitis B surface antigen (HBsAg) and hepatitis B core antigen (HBcAg). The expression pattern of these HBV antigens varies and is sometimes helpful in determining whether the liver injury is mainly from the HBV or from other causes in coexistence with the HBV infection.
- 5Histological grading of the necroinflammatory activity and staging of the fibrosis should only be applied when the changes are related to the recurrent HB.
- 6The pathology of liver transplantation is complex; therefore, clinical correlations remain extremely important in arriving at the final and correct diagnosis. Liver Transpl 12:S50–S53, 2006. © 2006 AASLD.
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