The immunobiology of schistosomiasis

EJ Pearce, AS MacDonald - Nature Reviews Immunology, 2002 - nature.com
EJ Pearce, AS MacDonald
Nature Reviews Immunology, 2002nature.com
Schistosomes are parasitic worms that are a prime example of a complex multicellular
pathogen that flourishes in the human host despite the development of a pronounced
immune response. Understanding how the immune system deals with such pathogens is a
daunting challenge. The past decade has seen the use of a wide range of new approaches
to determine the nature and function of the immune response to schistosomes. Here, we
attempt to summarize advances in our understanding of the immunology of schistosomiasis …
Abstract
Schistosomes are parasitic worms that are a prime example of a complex multicellular pathogen that flourishes in the human host despite the development of a pronounced immune response. Understanding how the immune system deals with such pathogens is a daunting challenge. The past decade has seen the use of a wide range of new approaches to determine the nature and function of the immune response to schistosomes. Here, we attempt to summarize advances in our understanding of the immunology of schistosomiasis, with the bulk of the review reflecting the experimental focus on Schistosoma mansoni infection in mice.
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