Pilot feasibility studies of leukocytapheresis with the Adacolumn Apheresis System in patients with active ulcerative colitis or Crohn disease
BE Sands, WJ Sandborn, DC Wolf, S Katz… - Journal of clinical …, 2006 - journals.lww.com
Background Patients with UC and CD, characterized by elevations in peripheral blood
granulocytes, monocytes/macrophages, and proinflammatory mediators, may benefit from
reductions in activated granulocytes and monocytes by selective apheresis. Methods
Patients underwent weekly Adacolumn sessions for 5 weeks. Pilot efficacy assessments
used disease activity index (DAI) for UC (0-12) or CD activity index (CDAI; 0-600) for CD.
Results Eleven of 15 UC patients completed all 5 treatments. Mean DAI scores fell from …
granulocytes, monocytes/macrophages, and proinflammatory mediators, may benefit from
reductions in activated granulocytes and monocytes by selective apheresis. Methods
Patients underwent weekly Adacolumn sessions for 5 weeks. Pilot efficacy assessments
used disease activity index (DAI) for UC (0-12) or CD activity index (CDAI; 0-600) for CD.
Results Eleven of 15 UC patients completed all 5 treatments. Mean DAI scores fell from …