Bleomycin (BLM) consists of a group of antibiotics isolated from a strain of Streptomyces
verticillus used primarily in the treatment of lymphomas, squamous cell carcinomas, and
testicular tumors." It is composed of sulfur-and copper-containing polypeptides and is
inactivated by a hydrolase enzyme that hydrolyzes an imide group." Unlike many antitumor
agents, there is minimal hematopoietic toxicity or immunosuppressive activity associated
with its use. 24 Unfortunately, a pulmonary toxicity dependent on both the total dose and …