Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers
D Cassiman, L Libbrecht, V Desmet, C Denef… - Journal of …, 2002 - Elsevier
Background/Aims: Hepatic stellate cells (HSC) are commonly considered the precursor
population of septal myofibroblasts (MF) in cirrhosis. We studied the distribution and
expression profile of mesenchymal (myo) fibroblast-like populations in fibrotic and cirrhotic
liver, in an attempt to elucidate their possible interrelationships. Methods: Fibrotic/cirrhotic
livers (from 22 human explants and from two rat models: carbon tetrachloride intoxication,
bile duct-ligation) were studied by means of immunohistochemistry (single and double …
population of septal myofibroblasts (MF) in cirrhosis. We studied the distribution and
expression profile of mesenchymal (myo) fibroblast-like populations in fibrotic and cirrhotic
liver, in an attempt to elucidate their possible interrelationships. Methods: Fibrotic/cirrhotic
livers (from 22 human explants and from two rat models: carbon tetrachloride intoxication,
bile duct-ligation) were studied by means of immunohistochemistry (single and double …