Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis
T Kisseleva, H Uchinami, N Feirt… - Journal of …, 2006 - Elsevier
BACKGROUND/AIMS: Hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis.
However, their origin is still unknown. We tested the hypothesis that bone marrow (BM)
contributes to the population of HSCs. METHODS: Chimeric mice transplanted with donor
BM from collagen α1 (I)-GFP+ reporter mice were subjected to the bile duct ligation (BDL)-
induced liver injury. RESULTS: In response to injury, BM-derived collagen-expressing GFP+
cells were detected in liver tissues of chimeric mice. However, these cells were not activated …
However, their origin is still unknown. We tested the hypothesis that bone marrow (BM)
contributes to the population of HSCs. METHODS: Chimeric mice transplanted with donor
BM from collagen α1 (I)-GFP+ reporter mice were subjected to the bile duct ligation (BDL)-
induced liver injury. RESULTS: In response to injury, BM-derived collagen-expressing GFP+
cells were detected in liver tissues of chimeric mice. However, these cells were not activated …