Infiltrating neutrophils in bile duct-ligated livers do not promote hepatic fibrosis
JM Saito, MK Bostick, CB Campe, J Xu, JJ Maher - Hepatology research, 2003 - Elsevier
Bile duct obstruction causes rapid infiltration of neutrophils into the liver and leads ultimately
to hepatic fibrosis. In this study, we assessed whether neutrophils play an active role in the
pathogenesis of hepatic fibrosis under conditions of biliary obstruction. We performed bile
duct ligation (BDL) on rats, some of which were depleted of neutrophils by means of an anti-
neutrophil antiserum. Rats treated with the antiserum had 48% fewer neutrophils than
control rats. Despite this, they showed no difference in either bile duct proliferation or hepatic …
to hepatic fibrosis. In this study, we assessed whether neutrophils play an active role in the
pathogenesis of hepatic fibrosis under conditions of biliary obstruction. We performed bile
duct ligation (BDL) on rats, some of which were depleted of neutrophils by means of an anti-
neutrophil antiserum. Rats treated with the antiserum had 48% fewer neutrophils than
control rats. Despite this, they showed no difference in either bile duct proliferation or hepatic …