Effects of gadolinium chloride (GdCl3) on the appearance of macrophage populations and fibrogenesis in thioacetamide-induced rat hepatic lesions
M Ide, M Kuwamura, T Kotani, O Sawamoto… - Journal of comparative …, 2005 - Elsevier
Macrophages infiltrating injured tissue play an important part in fibrogenesis. To shed light
on the functional roles of macrophages, we investigated the appearance of macrophage
populations in thioacetamide (TAA)-induced rat hepatic lesions, with or without pretreatment
with GdCl3, a chemical capable of inhibiting Kupffer cell functions. In the GdCl3+ TAA group
rats received a single intraperitoneal injection of GdCl3 (7.5 mg/kg body weight) and, after
24h, a single intravenous injection of TAA (300mg/kg body weight). Rats in the TAA group …
on the functional roles of macrophages, we investigated the appearance of macrophage
populations in thioacetamide (TAA)-induced rat hepatic lesions, with or without pretreatment
with GdCl3, a chemical capable of inhibiting Kupffer cell functions. In the GdCl3+ TAA group
rats received a single intraperitoneal injection of GdCl3 (7.5 mg/kg body weight) and, after
24h, a single intravenous injection of TAA (300mg/kg body weight). Rats in the TAA group …