Proangiogenic role of tumor-activated hepatic stellate cells in experimental melanoma metastasis
E Olaso, C Salado, E Egilegor, V Gutierrez… - Hepatology, 2003 - Elsevier
Myofibroblasts infiltrate malignant liver tumors, although their pathogenic implications are
unclear. Immunohistochemical detection of α-smooth muscle actin, glial fibrillary acidic
protein (GFAP), and CD31 and CD34 expression was used to analyze the contribution of
myofibroblasts to angiogenesis in hepatic metastasis produced by intrasplenically-injected
B16 melanoma (B16M). Because activated hepatic stellate cells (HSCs) are oxygen-sensing
myofibroblasts producing vascular endothelial growth factor (VEGF), the effect of B16M and …
unclear. Immunohistochemical detection of α-smooth muscle actin, glial fibrillary acidic
protein (GFAP), and CD31 and CD34 expression was used to analyze the contribution of
myofibroblasts to angiogenesis in hepatic metastasis produced by intrasplenically-injected
B16 melanoma (B16M). Because activated hepatic stellate cells (HSCs) are oxygen-sensing
myofibroblasts producing vascular endothelial growth factor (VEGF), the effect of B16M and …