Collagenase activity in experimental hepatic fibrosis
I Okazaki, K Maruyama - Nature, 1974 - nature.com
I Okazaki, K Maruyama
Nature, 1974•nature.comTHE collagen fibres newly formed in experimental hepatic fibrosis and pre-cirrhosis are
resorbed when the noxic stimuli have been removed1. In investigating the mechanism of
genesis and resorption of collagen fibres in experimental hepatic fibrosis2, 3 we have found
using electron microscopy that the collagen fibres are degraded extracellularly and partly
engulfed by Kupffer cells and/or macrophages4, 5. Within these cells digestion of collagen
fibrils or degraded collagen fibrils may occur in lysosomes6.
resorbed when the noxic stimuli have been removed1. In investigating the mechanism of
genesis and resorption of collagen fibres in experimental hepatic fibrosis2, 3 we have found
using electron microscopy that the collagen fibres are degraded extracellularly and partly
engulfed by Kupffer cells and/or macrophages4, 5. Within these cells digestion of collagen
fibrils or degraded collagen fibrils may occur in lysosomes6.
Abstract
THE collagen fibres newly formed in experimental hepatic fibrosis and pre-cirrhosis are resorbed when the noxic stimuli have been removed1. In investigating the mechanism of genesis and resorption of collagen fibres in experimental hepatic fibrosis2,3 we have found using electron microscopy that the collagen fibres are degraded extracellularly and partly engulfed by Kupffer cells and/or macrophages4,5. Within these cells digestion of collagen fibrils or degraded collagen fibrils may occur in lysosomes6.
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