[HTML][HTML] A choline-deficient diet in mice inhibits neither the CDP-choline pathway for phosphatidylcholine synthesis in hepatocytes nor apolipoprotein B secretion
A Kulinski, DE Vance, JE Vance - Journal of Biological Chemistry, 2004 - ASBMB
Phosphatidylcholine is a major component of very low density lipoproteins (VLDLs) secreted
by the liver. Hepatic phosphatidylcholine is synthesized from choline via the CDP-choline
pathway and from the phosphatidylethanolamine N-methyltransferase pathway. Elimination
of the methyltransferase in male mice reduces hepatic VLDL secretion. Our objective was to
determine whether inhibition of the CDP-choline pathway for phosphatidylcholine synthesis
(by restricting the supply of choline) also impaired VLDL secretion. In mice fed a choline …
by the liver. Hepatic phosphatidylcholine is synthesized from choline via the CDP-choline
pathway and from the phosphatidylethanolamine N-methyltransferase pathway. Elimination
of the methyltransferase in male mice reduces hepatic VLDL secretion. Our objective was to
determine whether inhibition of the CDP-choline pathway for phosphatidylcholine synthesis
(by restricting the supply of choline) also impaired VLDL secretion. In mice fed a choline …