Tissue inhibitor of metalloproteinases-1 promotes liver fibrosis development in a transgenic mouse model
H Yoshiji, S Kuriyama, Y Miyamoto, UP Thorgeirsson… - Hepatology, 2000 - Elsevier
Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been shown to be increased in liver
fibrosis development both in murine experimental models and human samples. However,
the direct role of TIMP-1 during liver fibrosis development has not been defined. To address
this issue, we developed transgenic mice overexpressing human TIMP-1 (hTIMP-1) in the
liver under control of the albumin promoter/enhancer. A model of CCl4-induced hepatic
fibrosis was used to assess the extent of fibrosis development in TIMP-1 transgenic (TIMP …
fibrosis development both in murine experimental models and human samples. However,
the direct role of TIMP-1 during liver fibrosis development has not been defined. To address
this issue, we developed transgenic mice overexpressing human TIMP-1 (hTIMP-1) in the
liver under control of the albumin promoter/enhancer. A model of CCl4-induced hepatic
fibrosis was used to assess the extent of fibrosis development in TIMP-1 transgenic (TIMP …