The neutrophil is a major effector cell of innate immunity. Exocytosis of granules and
secretory vesicles plays a pivotal role in most neutrophil functions from early activation to the
destruction of phagocytosed microorganisms. Neutrophil granules contain a multitude of
antimicrobial and potentially cytotoxic substances that are delivered to the phagosome or to
the exterior of the cell following degranulation. This review summarises current knowledge
of granule biology and highlights the effects of neutrophil degranulation in the acute …