Relative risk for cognitive impairments in siblings of patients with schizophrenia
MF Egan, TE Goldberg, T Gscheidle, M Weirich… - Biological …, 2001 - Elsevier
Background: Patients with schizophrenia have impairments in several domains of cognition,
including working memory/executive function, verbal memory, language, oculomotor
scanning/psychomotor speed, and general intelligence. Impairments have also been found
in unaffected siblings, suggesting they could be heritable. To assess the suitability of
cognitive dysfunction for use in genetic studies, we estimated relative risk (λ) in a large
cohort of siblings. Methods: One hundred forty-seven patients with schizophrenia, 193 of …
including working memory/executive function, verbal memory, language, oculomotor
scanning/psychomotor speed, and general intelligence. Impairments have also been found
in unaffected siblings, suggesting they could be heritable. To assess the suitability of
cognitive dysfunction for use in genetic studies, we estimated relative risk (λ) in a large
cohort of siblings. Methods: One hundred forty-seven patients with schizophrenia, 193 of …