[HTML][HTML] Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice
The role of macrophage lipoprotein lipase (LPL) expression in atherosclerotic lesion
formation was examined in low density lipoprotein receptor (LDLR−/−) mice using dietary
conditions designed to induce either fatty streak lesions or complex atherosclerotic lesions.
First, LDLR−/− mice chimeric for macrophage LPL expression were created by
transplantation of lethally irradiated female LDLR−/− mice with LPL−/−(n= 12) or LPL+/+(n=
14) fetal liver cells as a source of hematopoietic cells. To induce fatty streak lesions, these …
formation was examined in low density lipoprotein receptor (LDLR−/−) mice using dietary
conditions designed to induce either fatty streak lesions or complex atherosclerotic lesions.
First, LDLR−/− mice chimeric for macrophage LPL expression were created by
transplantation of lethally irradiated female LDLR−/− mice with LPL−/−(n= 12) or LPL+/+(n=
14) fetal liver cells as a source of hematopoietic cells. To induce fatty streak lesions, these …