[HTML][HTML] Identification and Characterization of HIPK2 Interacting with p73 and Modulating Functions of the p53 Familyin Vivo
EJ Kim, JS Park, SJ Um - Journal of Biological Chemistry, 2002 - ASBMB
To study the biological role of p73α, a member of the p53 tumor suppressor family, we
performed a yeast two-hybrid screen of a human cDNA library. Using a p73α fragment
consisting of amino acids 49–636 as bait, we found that p73α is functionally associated with
the human homologue of mouse and hamster homeodomain-interacting protein kinase 2
(HIPK2). The hamster homologue, also known as haHIPK2 or PKM, was used for further
characterization of interactions between HIPK2 and members of the p53 protein family …
performed a yeast two-hybrid screen of a human cDNA library. Using a p73α fragment
consisting of amino acids 49–636 as bait, we found that p73α is functionally associated with
the human homologue of mouse and hamster homeodomain-interacting protein kinase 2
(HIPK2). The hamster homologue, also known as haHIPK2 or PKM, was used for further
characterization of interactions between HIPK2 and members of the p53 protein family …