Sgk1 gene expression in kidney and its regulation by aldosterone: spatio-temporal heterogeneity and quantitative analysis
J Hou, HJL Speirs, JR Seckl… - Journal of the American …, 2002 - journals.lww.com
The serine-threonine kinase sgk1 was recently identified as a gene rapidly induced by
mineralocorticoids, resulting in increased sodium transport in vitro. To carefully localize and
quantify the renal sgk1 expression response to aldosterone, in situ hybridization was
performed on kidneys of mice having aldosterone excess over a range of doses and
durations. In control and adrenalectomized animals, the glomeruli and inner medullary
collecting ducts were the major sites of sgk1 expression, which was maintained independent …
mineralocorticoids, resulting in increased sodium transport in vitro. To carefully localize and
quantify the renal sgk1 expression response to aldosterone, in situ hybridization was
performed on kidneys of mice having aldosterone excess over a range of doses and
durations. In control and adrenalectomized animals, the glomeruli and inner medullary
collecting ducts were the major sites of sgk1 expression, which was maintained independent …