Agonists of proteinase-activated receptor 2 excite guinea pig ileal myenteric neurons
DR Linden, BP Manning, NW Bunnett… - European journal of …, 2001 - Elsevier
DR Linden, BP Manning, NW Bunnett, GM Mawe
European journal of pharmacology, 2001•ElsevierThe effects of proteinase-activated receptor 2 (PAR2) agonists on the electrical properties of
intact guinea pig ileal myenteric neurons were measured with intracellular microelectrodes.
Approximately 52% of AH neurons and 41% of S neurons responded to pressure ejection of
SLIGRL-NH2 or trypsin with a prolonged depolarization that was often accompanied by
increased excitability. When added to the bathing solution, trypsin caused a concentration-
dependent depolarization of responding neurons with an estimated EC50 value of 87 nM …
intact guinea pig ileal myenteric neurons were measured with intracellular microelectrodes.
Approximately 52% of AH neurons and 41% of S neurons responded to pressure ejection of
SLIGRL-NH2 or trypsin with a prolonged depolarization that was often accompanied by
increased excitability. When added to the bathing solution, trypsin caused a concentration-
dependent depolarization of responding neurons with an estimated EC50 value of 87 nM …
The effects of proteinase-activated receptor 2 (PAR2) agonists on the electrical properties of intact guinea pig ileal myenteric neurons were measured with intracellular microelectrodes. Approximately 52% of AH neurons and 41% of S neurons responded to pressure ejection of SLIGRL-NH2 or trypsin with a prolonged depolarization that was often accompanied by increased excitability. When added to the bathing solution, trypsin caused a concentration-dependent depolarization of responding neurons with an estimated EC50 value of 87 nM. Collectively, these novel observations indicate that PAR2 excites a proportion of myenteric neurons, which may contribute to dysmotility during intestinal inflammation.
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