[HTML][HTML] Mutations in a signalling pathway
Nature, 2005•nature.com
Protein kinases are enzymes that are important for controlling cellular growth and invasion,
and their malfunction is implicated in the development of some tumours. We analysed
human colorectal cancers for genetic mutations in 340 serine/threonine kinases and found
mutations in eight genes, including in three members of the phosphatidylinositol-3-OH
kinase (PI (3) K) pathway. The discovery of this mutational activation of a key cell-signalling
pathway may provide new targets for therapeutic intervention.
and their malfunction is implicated in the development of some tumours. We analysed
human colorectal cancers for genetic mutations in 340 serine/threonine kinases and found
mutations in eight genes, including in three members of the phosphatidylinositol-3-OH
kinase (PI (3) K) pathway. The discovery of this mutational activation of a key cell-signalling
pathway may provide new targets for therapeutic intervention.
Abstract
Protein kinases are enzymes that are important for controlling cellular growth and invasion, and their malfunction is implicated in the development of some tumours. We analysed human colorectal cancers for genetic mutations in 340 serine/threonine kinases and found mutations in eight genes, including in three members of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention.
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