In humans, a chronically increased circulating level of C-reactive protein (CRP), a positive
acute-phase reactant, is an independent risk factor for cardiovascular disease. This
observation has led to considerable interest in the role of inflammatory proteins in
atherosclerosis. In this review, after discussing CRP, we focus on the potential role in the
pathogenesis of human vascular disease of inflammation-induced proteins that are carried
by lipoproteins. Serum amyloid A (SAA) is transported predominantly on HDL, and levels of …