[HTML][HTML] Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE−/− and LDLR−/− mice
Endothelial lipase (EL) is a determinant of high density lipoprotein-cholesterol (HDL-C)
level, which is negatively correlated with atherosclerosis susceptibility. We found no
difference in aortic atherosclerotic lesion areas between 26-week-old EL+/+ apolipoprotein
E-deficient (apoE−/−) and EL−/− apoE−/− mice. To more firmly establish the role of EL in
atherosclerosis, we extended our study to EL−/− and EL+/+ low density lipoprotein receptor-
deficient (LDLR−/−) mice that were fed a Western diet. Morphometric analysis again …
level, which is negatively correlated with atherosclerosis susceptibility. We found no
difference in aortic atherosclerotic lesion areas between 26-week-old EL+/+ apolipoprotein
E-deficient (apoE−/−) and EL−/− apoE−/− mice. To more firmly establish the role of EL in
atherosclerosis, we extended our study to EL−/− and EL+/+ low density lipoprotein receptor-
deficient (LDLR−/−) mice that were fed a Western diet. Morphometric analysis again …