The mouse is now commonly used to explore the physiological changes that take place in
sterol metabolism when a specific protein function involved in cholesterol turnover is either
deleted or overexpressed. The major pathways for the net flow of cholesterol through the
tissue compartments of this species are outlined in Fig. 1. This diagram separates the overall
process of cholesterol turnover into those events that occur within the cells of the
extrahepatic tissues (90% of body mass), that promote movement through the plasma space …