The nuclear receptor superfamily is composed of transcription factors that positively and
negatively regulate gene expression in response to the binding of a diverse array of lipid-
derived hormones and metabolites. Intense efforts are currently being directed at defining
the biological roles and mechanisms of action of liver X receptors (LXRs) and peroxisome
proliferator-activated receptors (PPARs). LXRs have been found to play essential roles in
the regulation of whole body cholesterol absorption and excretion, in the efflux of cholesterol …