[HTML][HTML] Differential induction of glioblastoma migration and growth by two forms of pleiotrophin
KV Lu, KA Jong, GY Kim, J Singh, EQ Dia… - Journal of Biological …, 2005 - ASBMB
Glioblastoma is the most common malignant brain tumor of adults and one of the most lethal
cancers. The secreted growth factor pleiotrophin (PTN) promotes glioblastoma migration
and proliferation, initiating its oncogenic activities through two cell surface receptors, the
protein tyrosine phosphatase receptor ζ (PTPRZ1) and the anaplastic lymphoma kinase
(ALK), respectively. Here, we report on the presence and purification of two naturally
occurring forms of PTN (18 and 15 kDa) that differentially promote glioblastoma migration …
cancers. The secreted growth factor pleiotrophin (PTN) promotes glioblastoma migration
and proliferation, initiating its oncogenic activities through two cell surface receptors, the
protein tyrosine phosphatase receptor ζ (PTPRZ1) and the anaplastic lymphoma kinase
(ALK), respectively. Here, we report on the presence and purification of two naturally
occurring forms of PTN (18 and 15 kDa) that differentially promote glioblastoma migration …