NF-κB is a key transcription factor of lymphocytes and macrophages with important
regulatory functions in the immune system and inflammatory processes. These functions are
at least partially based on its ability to regulate the promoters of a variety of genes whose
products, such as cytokines, adhesion molecules and acute phase proteins, are critical for
inflammatory processes. In the present study, we describe a method to treat established
intestinal inflammation by local or systemic application of antisense phosphorothioate …