[HTML][HTML] Lymphoid neogenesis in murine cardiac allografts undergoing chronic rejection
FK Baddoura, IW Nasr, B Wrobel, Q Li… - American Journal of …, 2005 - Elsevier
Lymphoid neogenesis is the process by which ectopic lymphoid accumulations that
resemble lymph nodes arise in nonlymphoid tissues. Such lymphoid accumu-lations, known
as tertiary lymphoid organs (TLO), are observed in chronic autoimmunity and they propagate
immune pathology by setting up local antigen presenting sites. Whether lymphoid
neogenesis occurs in transplanted organs and contributes to rejection is not well
understood. To begin to address this question, we retrospectively analyzed 319 murine …
resemble lymph nodes arise in nonlymphoid tissues. Such lymphoid accumu-lations, known
as tertiary lymphoid organs (TLO), are observed in chronic autoimmunity and they propagate
immune pathology by setting up local antigen presenting sites. Whether lymphoid
neogenesis occurs in transplanted organs and contributes to rejection is not well
understood. To begin to address this question, we retrospectively analyzed 319 murine …