Brief, intermittent hypoxia restricts fetal growth in Sprague-Dawley rats
JE Schwartz, A Kovach, J Meyer, C McConnell… - Neonatology, 1998 - karger.com
JE Schwartz, A Kovach, J Meyer, C McConnell, HS Iwamoto
Neonatology, 1998•karger.comThis study was conducted to determine whether brief, intermittent exposure to hypoxia with
little change in nutrient intake would affect fetal growth. Pregnant rats were exposed to 1 or 2
h of hypoxia (FiO2= 0.09–0.095) from days 15 to 19 of gestation. Exposure to 1 h of hypoxia
decreased fetal body weight and length, liver weight and increased the brain/liver weight
ratio (p< 0.05) as compared to controls. Two hours of hypoxia decreased fetal body weight
and length, and heart, lung, kidney, gut, brain and liver weights (p< 0.01), but did not affect …
little change in nutrient intake would affect fetal growth. Pregnant rats were exposed to 1 or 2
h of hypoxia (FiO2= 0.09–0.095) from days 15 to 19 of gestation. Exposure to 1 h of hypoxia
decreased fetal body weight and length, liver weight and increased the brain/liver weight
ratio (p< 0.05) as compared to controls. Two hours of hypoxia decreased fetal body weight
and length, and heart, lung, kidney, gut, brain and liver weights (p< 0.01), but did not affect …
Abstract
This study was conducted to determine whether brief, intermittent exposure to hypoxia with little change in nutrient intake would affect fetal growth. Pregnant rats were exposed to 1 or 2 h of hypoxia (FiO2 = 0.09–0.095) from days 15 to 19 of gestation. Exposure to 1 h of hypoxia decreased fetal body weight and length, liver weight and increased the brain/liver weight ratio (p < 0.05) as compared to controls. Two hours of hypoxia decreased fetal body weight and length, and heart, lung, kidney, gut, brain and liver weights (p < 0.01), but did not affect the brain/liver weight ratio. Two hours of hypoxia decreased maternal food intake and weight gain (p < 0.05), but fetal growth was not significantly altered in pair-fed controls. These data demonstrate that brief, intermittent periods of intrauterine hypoxia have significant effects on fetal growth.
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