Changes in myocardial gene expression associated with β-blocker therapy in patients with chronic heart failure
Y Yasumura, K Takemura, A Sakamoto… - Journal of cardiac …, 2003 - Elsevier
BACKGROUND: The left ventricular functional recovery by β-blocker therapy is now
attributed to time-dependent biologic effects on cardiomyocytes. METHODS AND RESULTS:
To elucidate the cellular mechanism of these biologic effects, we treated 9 patients with
dilated cardiomyopathy for 4 months with β-blockers and examined the gene expressions
linked to an improvement of left ventricular ejection fraction (EF). Gene expressions of the
biopsied right ventricular endomyocardium were assessed by real-time reverse transcription …
attributed to time-dependent biologic effects on cardiomyocytes. METHODS AND RESULTS:
To elucidate the cellular mechanism of these biologic effects, we treated 9 patients with
dilated cardiomyopathy for 4 months with β-blockers and examined the gene expressions
linked to an improvement of left ventricular ejection fraction (EF). Gene expressions of the
biopsied right ventricular endomyocardium were assessed by real-time reverse transcription …