Differential Expression of MammalianTRPHomologues across Tissues and Cell Lines
RL Garcia, WP Schilling - Biochemical and biophysical research …, 1997 - Elsevier
Biochemical and biophysical research communications, 1997•Elsevier
Mammalian homologues of theDrosophila trpgene have been invoked as the structural
basis for the currents associated with capacitative Ca2+ entry (CCE) in many cell types.
Trphomologues are members of a large protein family that may associate as channel
subunits providing an explanation for the functional diversity of store-operated channels
observed in these cells. However, there is little information as to which of these genes are co-
expressed at the cellular level. We have examined the tissue specific expression of five …
basis for the currents associated with capacitative Ca2+ entry (CCE) in many cell types.
Trphomologues are members of a large protein family that may associate as channel
subunits providing an explanation for the functional diversity of store-operated channels
observed in these cells. However, there is little information as to which of these genes are co-
expressed at the cellular level. We have examined the tissue specific expression of five …
Mammalian homologues of theDrosophila trpgene have been invoked as the structural basis for the currents associated with capacitative Ca2+entry (CCE) in many cell types.Trphomologues are members of a large protein family that may associate as channel subunits providing an explanation for the functional diversity of store-operated channels observed in these cells. However, there is little information as to which of these genes are co-expressed at the cellular level. We have examined the tissue specific expression of five mammaliantrpgenes and determined which are co-expressed in five different cell lines. The results show tissue- and cell-specific co-expression of multipletrpforms. This implies that the subunit composition of a particular CCE channel may vary depending on the cell type.
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