[HTML][HTML] Formation of novel TRPC channels by complex subunit interactions in embryonic brain
C Strubing, G Krapivinsky, L Krapivinsky… - Journal of Biological …, 2003 - ASBMB
Mammalian short TRP channels (TRPCs) are putative receptor-and store-operated cation
channels that play a fundamental role in the regulation of cellular Ca 2+ homeostasis.
Assembly of the seven TRPC homologs (TRPC1-7) into homo-and heteromers can create a
large variety of different channels. However, the compositions as well as the functional
properties of native TRPC complexes are largely undefined. We performed a systematic
biochemical study of TRPC interactions in mammalian brain and identified previously …
channels that play a fundamental role in the regulation of cellular Ca 2+ homeostasis.
Assembly of the seven TRPC homologs (TRPC1-7) into homo-and heteromers can create a
large variety of different channels. However, the compositions as well as the functional
properties of native TRPC complexes are largely undefined. We performed a systematic
biochemical study of TRPC interactions in mammalian brain and identified previously …