Store-operated Ca2+ entry uncoupled with ryanodine receptor and junctional membrane complex in heart muscle cells
A Uehara, M Yasukochi, I Imanaga, M Nishi… - Cell calcium, 2002 - Elsevier
Store-operated Ca2+ entry (SOCE) is the Ca2+ influx that is activated on depletion of
intracellular Ca2+ stores. Although SOCE is found in a variety of cell types, its activation
mechanism and molecular identity remain to be clarified. Current experimental results
suggest that SOCE channels are activated by direct coupling with Ca2+ release channels on
depleted stores. Here we report SOCE in cardiac myocytes, that was prominently sensitive to
Zn2+ but resistant to inhibitors for voltage-dependent Ca2+ channels and Na+/Ca2+ …
intracellular Ca2+ stores. Although SOCE is found in a variety of cell types, its activation
mechanism and molecular identity remain to be clarified. Current experimental results
suggest that SOCE channels are activated by direct coupling with Ca2+ release channels on
depleted stores. Here we report SOCE in cardiac myocytes, that was prominently sensitive to
Zn2+ but resistant to inhibitors for voltage-dependent Ca2+ channels and Na+/Ca2+ …