[HTML][HTML] Calmodulin mediates Ca2+ sensitivity of sodium channels
J Kim, S Ghosh, H Liu, M Tateyama, RS Kass… - Journal of Biological …, 2004 - ASBMB
Ca 2+ has been proposed to regulate Na+ channels through the action of calmodulin (CaM)
bound to an IQ motif or through direct binding to a paired EF hand motif in the Na v 1 C
terminus. Mutations within these sites cause cardiac arrhythmias or autism, but details about
how Ca 2+ confers sensitivity are poorly understood. Studies on the homologous Ca v 1.2
channel revealed non-canonical CaM interactions, providing a framework for exploring Na+
channels. In contrast to previous reports, we found that Ca 2+ does not bind directly to Na+ …
bound to an IQ motif or through direct binding to a paired EF hand motif in the Na v 1 C
terminus. Mutations within these sites cause cardiac arrhythmias or autism, but details about
how Ca 2+ confers sensitivity are poorly understood. Studies on the homologous Ca v 1.2
channel revealed non-canonical CaM interactions, providing a framework for exploring Na+
channels. In contrast to previous reports, we found that Ca 2+ does not bind directly to Na+ …