Obligatory role of cholesterol and apolipoprotein E in the formation of large cholesterol-enriched and receptor-active high density lipoproteins.
C Koo, TL Innerarity, RW Mahley - Journal of Biological Chemistry, 1985 - ASBMB
The formation of large cholesterol-enriched high density lipoproteins (HDL1/HDLc) from
typical HDL3 requires lecithin: cholesterol acyltransferase activity, additional cholesterol,
and a source of apolipoprotein (apo-) E. The present study explores the role of apo-E in
promoting HDL1/HDLc formation and in imparting to these lipoprotein particles the ability to
interact with the apo-B, E (low density lipoprotein (LDL] receptor. Incubation of normal
canine serum with cholesterol-loaded mouse peritoneal macrophages resulted in the …
typical HDL3 requires lecithin: cholesterol acyltransferase activity, additional cholesterol,
and a source of apolipoprotein (apo-) E. The present study explores the role of apo-E in
promoting HDL1/HDLc formation and in imparting to these lipoprotein particles the ability to
interact with the apo-B, E (low density lipoprotein (LDL] receptor. Incubation of normal
canine serum with cholesterol-loaded mouse peritoneal macrophages resulted in the …