Human papillomavirus biology and cervical neoplasia: implications for diagnostic criteria and testing

MH Stoler - Archives of pathology & laboratory medicine, 2003 - meridian.allenpress.com
MH Stoler
Archives of pathology & laboratory medicine, 2003meridian.allenpress.com
Human papillomaviruses are necessary for the development of cervical neoplasia. Progress
in our understanding of the epithelial biology of this common pathogen has greatly
influenced current concepts of cervical carcinogenesis. This understanding has provided a
framework for understanding the biologic basis of many diagnostic criteria. Furthermore,
classification schemes, diagnostic testing, and clinical management have been modified
and clarified in light of this knowledge.
Abstract
Human papillomaviruses are necessary for the development of cervical neoplasia. Progress in our understanding of the epithelial biology of this common pathogen has greatly influenced current concepts of cervical carcinogenesis. This understanding has provided a framework for understanding the biologic basis of many diagnostic criteria. Furthermore, classification schemes, diagnostic testing, and clinical management have been modified and clarified in light of this knowledge.
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