Breast cancer metastasis to bone: it is not all about PTHrP
M Bendre, D Gaddy, RW Nicholas… - … and Related Research®, 2003 - journals.lww.com
Breast cancer shows a predilection for metastasis to bone. Interestingly, approximately 80%
of patients with breast cancer also have bone metastases develop at some point during the
course of their disease. Osteolytic breast cancer induces bonedestruction via the stimulation
of osteoclasts. Breast cancer cells produce many known stimulators of bone resorption with
significant research effort focused on the role of parathyroid hormone-related protein
(PTHrP). However, a recent prospective clinical trial has questioned the primary role of …
of patients with breast cancer also have bone metastases develop at some point during the
course of their disease. Osteolytic breast cancer induces bonedestruction via the stimulation
of osteoclasts. Breast cancer cells produce many known stimulators of bone resorption with
significant research effort focused on the role of parathyroid hormone-related protein
(PTHrP). However, a recent prospective clinical trial has questioned the primary role of …